The Candida albicans Ddr48 protein is essential for filamentation, stress response, and confers partial antifungal drug resistance.

@article{Dib2008TheCA,
  title={The Candida albicans Ddr48 protein is essential for filamentation, stress response, and confers partial antifungal drug resistance.},
  author={Leila Mohammed Dib and Peter Jose Hayek and Helen Sadek and Berna Beyrouthy and Roy A Khalaf},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2008},
  volume={14 6},
  pages={
          BR113-121
        }
}
BACKGROUND Candida albicans is a dimorphic pathogenic fungus that causes mucosal and systemic infections. C. albicans pathogenicity is attributed to its ability to exist in different morphologic states and to respond to stress by up regulating several key genes. DDR48 is a stress-associated gene involved in DNA repair and in response to antifungal drug exposure. MATERIAL/METHODS One allele of DDR48 was knocked out by homologous recombination that inserted a marker cassette in its position… CONTINUE READING

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