The Candida Genome Database (CGD), a community resource for Candida albicans gene and protein information

@article{Arnaud2005TheCG,
  title={The Candida Genome Database (CGD), a community resource for Candida albicans gene and protein information},
  author={Martha B. Arnaud and Maria C. Costanzo and Marek S. Skrzypek and Gail Binkley and Christopher Lane and Stuart R. Miyasato and Gavin Sherlock},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={D358 - D363}
}
The Candida Genome Database (CGD) is a new database that contains genomic information about the opportunistic fungal pathogen Candida albicans. CGD is a public resource for the research community that is interested in the molecular biology of this fungus. CGD curators are in the process of combing the scientific literature to collect all C.albicans gene names and aliases; to assign gene ontology terms that describe the molecular function, biological process, and subcellular localization of each… 

Figures and Tables from this paper

Sequence resources at the Candida Genome Database
TLDR
The sequence information available for C.albicans, the sequence information contained in CGD, and the tools for sequence retrieval, analysis and comparison that CGD provides are described.
The Candida Genome Database: The new homology information page highlights protein similarity and phylogeny
TLDR
A new tab is added to the Locus page, entitled the Homology Information tab, which displays phylogeny and gene similarity information for each locus, in this update to previous NAR Database articles featuring CGD.
The Candida Genome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data
TLDR
The incorporation into CGD of Assembly 22, the first chromosome-level, phased diploid assembly of the C. albicans genome, is reported, coupled with improvements that have been made to the assembly using additional available sequence data.
CandidaDB: a multi-genome database for Candida species and related Saccharomycotina
TLDR
The new version of CandidaDB houses the latest versions of the genomes of C.Albicans strains SC5314 and WO-1 along with six genome sequences from species closely related to C. albicans and the reference Saccharomyces cerevisiae genome.
Improved Gene Ontology Annotation for Biofilm Formation, Filamentous Growth, and Phenotypic Switching in Candida albicans
TLDR
A set of C. albicans genes at the intersection of biofilm formation, filamentous growth, pathogenesis, and phenotypic switching of this opportunistic fungal pathogen is defined, which provides a compelling list of candidates for further experimentation.
YeastSCI: A Web Tool Integrating Zinc Cluster Protein Information of Saccharomyces and Candida
TLDR
A web tool accessible online called Yeast Saccharomyces and Candida Integrated (YeastSCI) is developed, which provides the integration information of Saccharomeces andcandida from popular databases and a hybrid cacheable technique is proposed to make the tool self-updatable and provide a real-time information efficiently.
A Human-Curated Annotation of the Candida albicans Genome
TLDR
Improved annotation permitted a detailed analysis of several multigene families, and comparative genomic studies showed that C. albicans has a far greater catabolic range, encoding respiratory Complex 1, several novel oxidoreductases and ketone body degrading enzymes, malonyl- CoA and enoyl-CoA carriers, and numerous transporters to assimilate the resulting nutrients.
Tetrahymena genome database Wiki: a community-maintained model organism database
TLDR
The Tetrahymena Genome Database (TGD) website is restored and updated to allow members of the community to directly update the information presented for each gene, including gene names, descriptions and Gene Ontology annotations, from a web browser.
Proteopathogen, a protein database for studying Candida albicans – host interaction
TLDR
Proteopathogen is a database intended to compile proteomics experimental data and to facilitate storage and access to a range of data which spans proteomics workflows from description of the experimental approaches leading to sample preparation to MS settings and peptides supporting protein identification.
The Comprehensive Phytopathogen Genomics Resource: a web-based resource for data-mining plant pathogen genomes
The Comprehensive Phytopathogen Genomics Resource (CPGR) provides a web-based portal for plant pathologists and diagnosticians to view the genome and trancriptome sequence status of 806 bacterial,
...
...

References

SHOWING 1-10 OF 18 REFERENCES
Saccharomyces Genome Database (SGD) provides tools to identify and analyze sequences from Saccharomyces cerevisiae and related sequences from other organisms
TLDR
The Saccharomyces Genome Database has recently developed several new resources that allow the comparison and integration of information on a genome-wide scale, enabling the user not only to find detailed information about individual genes, but also to make connections across groups of genes with common features and across different species.
The Pathway Tools software
TLDR
This paper provides an overview of the four main components of the Pathway Tools: the PathoLogic component supports creation of new PGDBs from the annotated genome of an organism, and the pathway/Genome Navigator provides query, visualization, and Web-publishing services forPGDBs.
The diploid genome sequence of Candida albicans.
TLDR
Computational methods are developed to assemble a diploid genome sequence in good agreement with available physical mapping data and provide a whole-genome description of heterozygosity in the organism.
Gene Ontology: tool for the unification of biology
TLDR
The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing.
Thirteen-Year Evolution of Azole Resistance in Yeast Isolates and Prevalence of Resistant Strains Carried by Cancer Patients at a Large Medical Center
TLDR
Monitoring of susceptibility to antifungal agents appears to be necessary for optimizing clinical therapeutic decision making in hematologic malignancy and transplant patients.
Emergence of azole drug resistance in Candida species from HIV-infected patients receiving prolonged fluconazole therapy for oral candidosis.
TLDR
The experience with C. albicans in patients with HIV infection, suggests that the long-term azole drug use may be an important factor in the development of fluconazole resistance as such resistance was rare and transient in patients on intermittent short-term treatment.
Antifungal agents: chemotherapeutic targets and immunologic strategies
TLDR
This minireview briefly discusses the antifungal agents currently in clinical use, and considers the use of promising new biochemical targets in fungi as well as host-based, immunological approaches as evolving strategies for antIFungal therapy.
Opportunistic candidiasis: an epidemic of the 1980s.
  • S. Fisher-Hoch, L. Hutwagner
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1995
TLDR
The rate of debilitating and life-threatening candidiasis among hospitalized patients increased considerably over the 1980s and was significant among patients with HIV infection/AIDS and patients undergoing transplantation or immunosuppressive therapy for malignancies.
Goodman and Gilman's The Pharmacological Basis of Therapeutics
TLDR
Clinicians who frequently face difficult decisions about dosage should be aware that the book closes with an 80-page table of pharmacokinetic data relevant to dosage adjustment, and the editors clearly see clinicians and clinicians-to-be as their main audience, andThe text reflects this.
Emerging targets for the development of novel antifungal therapeutics.
...
...