The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity

  title={The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity},
  author={Jordi G Barretina and Giordano Caponigro and Nicolas Stransky and Kavitha Venkatesan and Adam A. Margolin and Sungjoon Kim and Christopher J Wilson and Joseph Lehar and Gregory V. Kryukov and Dmitriy Sonkin and Anupama Reddy and Manway Liu and Lauren Murray and Michael F. Berger and John E. Monahan and Paula Cristina Ara{\'u}jo Morais and Jodi Meltzer and Adam Korejwa and Judit Jan{\'e}-Valbuena and Felipa A. Mapa and Joseph Thibault and Eva Bric-Furlong and Pichai Raman and Aaron Shipway and Ingo H. Engels and Jill Cheng and Guoying K. Yu and Jianjun Yu and Peter Aspesi and Melanie de Silva and Kalpana Jagtap and Michael D. Jones and Li Chun Wang and Charles Hatton and Emanuele Palescandolo and Supriya Gupta and Scott Mahan and Carrie L. Sougnez and Robert C. Onofrio and Ted Liefeld and Laura E Macconaill and Wendy Winckler and Michael R Reich and Nanxin Li and Jill P. Mesirov and Stacey Bolk Gabriel and Gad Getz and Kristin G. Ardlie and Vivien W Chan and Vic E. Myer and Barbara L. Weber and Jeff A. Porter and Markus Warmuth and Peter M. Finan and Jennifer L. Harris and Matthew L Meyerson and Todd R. Golub and Michael P. Morrissey and William R Sellers and Robert W. Schlegel and Levi A. Garraway},
The systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust preclinical model systems that reflect the genomic diversity of human cancers and for which detailed genetic and pharmacological annotation is available. Here we describe the Cancer Cell Line Encyclopedia (CCLE): a compilation of gene expression, chromosomal copy number and massively parallel sequencing data from 947… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS