The Calcium-mobilizing Messenger Nicotinic Acid Adenine Dinucleotide Phosphate Participates in Sperm Activation by Mediating the Acrosome Reaction*

@inproceedings{Vasudevan2010TheCM,
  title={The Calcium-mobilizing Messenger Nicotinic Acid Adenine Dinucleotide Phosphate Participates in Sperm Activation by Mediating the Acrosome Reaction*},
  author={Sridhar R. Vasudevan and Alexander M. Lewis and Jennifer A W Chan and Claire L. Machin and Debroshi Sinha and Antony Galione and Grant C. Churchill},
  booktitle={The Journal of biological chemistry},
  year={2010}
}
Before a sperm can fertilize an egg it must undergo a final activation step induced by the egg termed the acrosome reaction. During the acrosome reaction a lysosome-related organelle, the acrosome, fuses with the plasma membrane to release hydrolytic enzymes and expose an egg-binding protein. Because NAADP (nicotinic acid adenine dinucleotide phosphate) releases Ca(2+) from acidic lysosome-related organelles in other cell types, we investigated a possible role for NAADP in mediating the… CONTINUE READING

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