The Calcium Channel Blocker Verapamil Inhibits Oxidative Stress Response in Candida albicans

@article{Yu2014TheCC,
  title={The Calcium Channel Blocker Verapamil Inhibits Oxidative Stress Response in Candida albicans},
  author={Qilin Yu and Chenpeng Xiao and Kailun Zhang and Chang Jiu Jia and Xiaohui Ding and Bing Zhang and Yong Wang and Mingchun Li},
  journal={Mycopathologia},
  year={2014},
  volume={177},
  pages={167-177}
}
Candida albicans is a common opportunistic fungal pathogen, causing both superficial candidiasis and life-threatening systemic infections in immune-compromised individuals. Calcium signaling is responsible for this pathogen in responding to several stresses, such as antifungal drugs, alkaline pH and membrane-perturbing agents. Our recent study revealed that it is also involved in oxidative stress response. In this study, we investigated the effect of verapamil, an L-type voltage-gated calcium… CONTINUE READING