The Calcineurin Regulator Sra Plays an Essential Role in Female Meiosis in Drosophila

@article{Takeo2006TheCR,
  title={The Calcineurin Regulator Sra Plays an Essential Role in Female Meiosis in Drosophila},
  author={Satomi Takeo and Manabu Tsuda and Shin Akahori and Takashi Matsuo and Toshiro Aigaki},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={1435-1440}
}
Modulatory calcineurin-interacting proteins (MCIPs)--also termed regulators of calcineurin (RCNs), calcipressins, or DSCR1 (Down's syndrome critical region 1)--are highly conserved regulators of calcineurin, a Ca(2+)/calmodulin-dependent protein phosphatase . Although overexpression experiments in several organisms have revealed that MCIPs inhibit calcineurin activity , their in vivo functions remain unclear. Here, we show that the Drosophila MCIP sarah (sra) is essential for meiotic… CONTINUE READING

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