The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA.

@article{Mullen2006TheCE,
  title={The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA.},
  author={Gregory P. Mullen and Eleanor A. Mathews and Paurush Saxena and Stephen D. Fields and John Ryan McManus and Gary L Moulder and Robert J. Barstead and Michael W. Quick and James B. Rand},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 7},
  pages={
          3021-30
        }
}
Sodium-dependent neurotransmitter transporters participate in the clearance and/or recycling of neurotransmitters from synaptic clefts. The snf-11 gene in Caenorhabditis elegans encodes a protein of high similarity to mammalian GABA transporters (GATs). We show here that snf-11 encodes a functional GABA transporter; SNF-11-mediated GABA transport is Na+ and Cl- dependent, has an EC50 value of 168 microM, and is blocked by the GAT1 inhibitor SKF89976A. The SNF-11 protein is expressed in seven… CONTINUE READING
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