The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo.

@article{Morton2002TheCE,
  title={The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo.},
  author={Diane G. Morton and Diane C Shakes and Staci Nugent and Daryl Dichoso and Wenfu Wang and Andy Golden and Kenneth J. Kemphues},
  journal={Developmental biology},
  year={2002},
  volume={241 1},
  pages={47-58}
}
The establishment of anterior-posterior polarity in the Caenorhabditis elegans embryo requires the activity of the maternally expressed par genes. We report the identification and analysis of a new par gene, par-5. We show that par-5 is required for asynchrony and asymmetry in the first embryonic cell divisions, normal pseudocleavage, normal cleavage spindle orientation at the two-cell stage, and localization of P granules and MEX-5 during the first and subsequent cell cycles. Furthermore, par… CONTINUE READING
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