The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch

@article{Yochem1988TheCE,
  title={The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch},
  author={John Yochem and Kathleen Weston and Iva Greenwald},
  journal={Nature},
  year={1988},
  volume={335},
  pages={547-550}
}
The lin-12 gene seems to control certain binary decisions during Caenorhabditis elegans development, from genetic and anatomical studies of lin-12 mutants that have either elevated or reduced levels of lin-12 activity1. We report here the complete DNA sequence of lin-12:13.5 kilobases (kb) derived from genomic clones and 4.5 kb from complementary DNA clones. It is of interest that the predicted product is a putative transmembrane protein, given that many of the decisions controlled by lin-12… CONTINUE READING

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