The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia.

@article{Jiang2001TheCE,
  title={The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia.},
  author={Hongxin Jiang and Robin Guo and Jo Anne Powell-Coffman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 14},
  pages={
          7916-21
        }
}
Hypoxia-inducible factor, a heterodimeric transcription complex, regulates cellular and systemic responses to low oxygen levels (hypoxia) during normal mammalian development or tumor progression. Here, we present evidence that a similar complex mediates response to hypoxia in Caenorhabditis elegans. This complex consists of HIF-1 and AHA-1, which are encoded by C. elegans homologs of the hypoxia-inducible factor (HIF) alpha and beta subunits, respectively. hif-1 mutants exhibit no severe… CONTINUE READING

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