The Caenorhabditis elegans heterochronic gene pathway controls stage-specific transcription of collagen genes.

@article{Liu1995TheCE,
  title={The Caenorhabditis elegans heterochronic gene pathway controls stage-specific transcription of collagen genes.},
  author={Zhijie Liu and Susan A. Kirch and Victor Robert Ambros},
  journal={Development},
  year={1995},
  volume={121 8},
  pages={2471-8}
}
In Caenorhabditis elegans, the terminal differentiation of the hypodermal cells occurs at the larval-to-adult molt, and is characterized in part by the formation of a morphologically distinct adult cuticle. The timing of this event is controlled by a pathway of heterochronic genes that includes the relatively direct regulatory gene, lin-29, and upstream genes lin-4, lin-14 and lin-28. Using northern analysis to detect endogenous collagen mRNA levels and collagen/lacZ reporter constructs to… CONTINUE READING