The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions.

@article{Herman1994TheCE,
  title={The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions.},
  author={M. A. Herman and H Robert Horvitz},
  journal={Development},
  year={1994},
  volume={120 5},
  pages={1035-47}
}
The generation and orientation of cellular and organismic polarity are fundamental aspects of development. Mutations in the gene lin-44 of the nematode Caenorhabditis elegans reverse both the relative positions of specific sister cells and the apparent polarities of these cells. Thus, lin-44 mutants appear to generate polar cells but to misorient these cells along the body axis of the animal. We postulate that lin-44 acts to specify the orientation of polar cells. 

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