The Caenorhabditis elegans gene lin-26 can trigger epithelial differentiation without conferring tissue specificity.

@article{Quintin2001TheCE,
  title={The Caenorhabditis elegans gene lin-26 can trigger epithelial differentiation without conferring tissue specificity.},
  author={Sophie Quintin and Gr{\'e}goire Michaux and Laura A. McMahon and Anne Gansmuller and Michel Labouesse},
  journal={Developmental biology},
  year={2001},
  volume={235 2},
  pages={410-21}
}
How epithelial cell fates become specified is poorly understood. We have previously shown that the putative C2H2 zinc-finger transcription factor LIN-26 is required for the differentiation of ectodermal and mesodermal epithelial cells in Caenorhabditis elegans. Here, we report that ectopic LIN-26 expression during early gastrulation transforms most blastomeres into epithelial-like cells. Specifically, LIN-26 induced the expression of three epithelial markers: the adherens junction protein JAM-1… CONTINUE READING
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