The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.

@article{Lucanic2006TheCE,
  title={The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.},
  author={Mark Lucanic and Maureen Kiley and Neville Ashcroft and Noelle L'etoile and Hwai-Jong Cheng},
  journal={Development},
  year={2006},
  volume={133 22},
  pages={4549-59}
}
P21 activated kinases (PAKs) are major downstream effectors of rac-related small GTPases that regulate various cellular processes. We have identified the new PAK gene max-2 in a screen for mutants disrupted in UNC-6/netrin-mediated commissural axon guidance. There are three Caenorhabditis elegans PAKs. We find that each C. elegans PAK represents a distinct group previously identified in other species. Here we examine their roles in the postembryonic migration of the P cell neuroblasts and the… CONTINUE READING