The Cadherins Fat and Dachsous Regulate Dorsal/Ventral Signaling in the Drosophila Eye

  title={The Cadherins Fat and Dachsous Regulate Dorsal/Ventral Signaling in the Drosophila Eye},
  author={Amy S. Rawls and Jake B. Guinto and Tanya Wolff},
  journal={Current Biology},
The Drosophila eye is a polarized epithelium in which ommatidia of opposing chirality fall on opposite sides of the eye's midline, the equator. The equator is established in at least two steps: photoreceptors R3 and R4 adopt their fates, and then ommatidia rotate clockwise or counterclockwise in accordance with the identity of these photoreceptors. We report the role of two cadherins, Fat (Ft) and Dachsous (Ds), in conveying the polarizing signal from the D/V midline in the Drosophila eye. In… CONTINUE READING

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