The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics

@article{Sambuy2005TheCC,
  title={The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics},
  author={Y. Sambuy and I. D. Angelis and G. Ranaldi and M. L. Scarino and A. Stammati and F. Zucco},
  journal={Cell Biology and Toxicology},
  year={2005},
  volume={21},
  pages={1-26}
}
  • Y. Sambuy, I. D. Angelis, +3 authors F. Zucco
  • Published 2005
  • Medicine, Biology
  • Cell Biology and Toxicology
  • The human intestinal Caco-2 cell line has been extensively used over the last twenty years as a model of the intestinal barrier. The parental cell line, originally obtained from a human colon adenocarcinoma, undergoes in culture a process of spontaneous differentiation that leads to the formation of a monolayer of cells, expressing several morphological and functional characteristics of the mature enterocyte. Culture-related conditions were shown to influence the expression of these… CONTINUE READING
    Good Caco-2 cell culture practices.
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