The Ca2+ release channel in junctional sarcoplasmic reticulum: gating and blockade by cations.

@article{Soler1992TheCR,
  title={The Ca2+ release channel in junctional sarcoplasmic reticulum: gating and blockade by cations.},
  author={Fernando Soler and Francisco Fern{\'a}ndez-Belda and Juan C G{\'o}mez-Fern{\'a}ndez},
  journal={The International journal of biochemistry},
  year={1992},
  volume={24 6},
  pages={903-9}
}
1. By using a sarcoplasmic reticulum preparation containing feet structures and the 45Ca2+/filtration technique, the opening and closing response of the Ca(2+)-channel was studied. 2. Extravesicular Sr2+ can activate the channel even though this cation is less efficient than Ca2+ in stimulating the Ca2+ release. Higher Sr2+ concentrations display inhibitory action. 3. By studying the closing response high- and low-affinity cations can be distinguished, according to the concentration range… CONTINUE READING

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