The Ca2+ channel blocker flunarizine induces caspase-10-dependent apoptosis in Jurkat T-leukemia cells

@article{Conrad2010TheCC,
  title={The Ca2+ channel blocker flunarizine induces caspase-10-dependent apoptosis in Jurkat T-leukemia cells},
  author={David M. Conrad and Suzanne J. Furlong and Carolyn D. Doucette and Kenneth A. West and David W. Hoskin},
  journal={Apoptosis},
  year={2010},
  volume={15},
  pages={597-607}
}
Flunarizine is a Ca2+ channel blocker that can be either cytoprotective or cytotoxic, depending on the cell type that is being examined. We show here that flunarizine was cytotoxic for Jurkat T-leukemia cells, as well as for other hematological maligancies, but not for breast or colon carcinoma cells. Treatment of Jurkat cells with flunarizine resulted in caspase-3 activation, poly (ADP-ribose) polymerase cleavage, and laddering of DNA fragments, all of which are hallmarks of apoptosis… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Mechanisms of cell death in oxidative stress.

Antioxidants & redox signaling • 2007
View 2 Excerpts

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