The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes.

@article{Thorey2001TheCP,
  title={The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes.},
  author={Irmgard S. Thorey and Johannes Roth and Johannes Regenbogen and J P Halle and Michael Bittner and Thomas Vogl and Susanne Kaesler and Philippe Bugnon and Birgit Reitmaier and Silke S Durka and Anastasia Graf and M W{\"o}ckner and Norman Rieger and A Konstantinow and Eckhard Wolf and Andreas Goppelt and Sabine Werner},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 38},
  pages={35818-25}
}
To gain insight into the molecular mechanisms underlying cutaneous wound repair, we performed a large scale screen to identify novel injury-regulated genes. Here we show a strong up-regulation of the RNA and protein levels of the two Ca(2+)-binding proteins S100A8 and S100A9 in the hyperthickened epidermis of acute murine and human wounds and of human ulcers. Furthermore, both genes were expressed by inflammatory cells in the wound. The increased expression of S100A8 and S100A9 in wound… CONTINUE READING

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