The Ca2+- and reduced nicotinamide adenine dinucleotide phosphate-dependent hydrogen peroxide generating system is induced by thyrotropin in porcine thyroid cells.

@article{Carvalho1996TheCA,
  title={The Ca2+- and reduced nicotinamide adenine dinucleotide phosphate-dependent hydrogen peroxide generating system is induced by thyrotropin in porcine thyroid cells.},
  author={Denise P. Carvalho and Corinne Dupuy and Yu. P. Gorin and O Legu{\'e} and Janine Pommier and B Muller Haye and Alain Virion},
  journal={Endocrinology},
  year={1996},
  volume={137 3},
  pages={
          1007-12
        }
}
Hydrogen peroxide (H2O2) is an essential electron acceptor for thyroid peroxidase-catalyzed iodination and coupling reactions. In the presence of iodide, its production is a limiting step in thyroid hormone biosynthesis. Several studies have demonstrated that the thyroid particulate fraction contains a Ca2+- and NADPH- dependent H@O@ generator (NADPH-O2:oxidoreductase), the so- called thyroid NADPH-oxidase. It has recently been demonstrated that cellular H2O2 release is under the tonic control… CONTINUE READING
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