The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate.

@article{Nilius2006TheCC,
  title={The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate.},
  author={Bernd Nilius and Frank Mahieu and Jean Prenen and A. CecileJ.W. Janssens and Grzegorz Owsianik and Rudi Vennekens and Thomas Voets},
  journal={The EMBO journal},
  year={2006},
  volume={25 3},
  pages={467-78}
}
Transient receptor potential (TRP) channel, melastatin subfamily (TRPM)4 is a Ca2+-activated monovalent cation channel that depolarizes the plasma membrane and thereby modulates Ca2+ influx through Ca2+-permeable pathways. A typical feature of TRPM4 is its rapid desensitization to intracellular Ca2+ ([Ca2+]i). Here we show that phosphatidylinositol 4,5-biphosphate (PIP2) counteracts desensitization to [Ca2+]i in inside-out patches and rundown of TRPM4 currents in whole-cell patch-clamp… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
104 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 104 extracted citations

Similar Papers

Loading similar papers…