The Ca2+ ATPase of cardiac sarcoplasmic reticulum: Physiological role and relevance to diseases.

@article{Inesi2008TheCA,
  title={The Ca2+ ATPase of cardiac sarcoplasmic reticulum: Physiological role and relevance to diseases.},
  author={Giuseppe Inesi and Anand M. Prasad and Rajendra Pilankatta},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={369 1},
  pages={182-7}
}
The Ca(2+) ATPase of sarcoplasmic reticulum has a prominent role in excitation/contraction coupling of cardiac muscle, as it induces relaxation by sequestering Ca(2+) from the cytoplasm. The stored Ca(2+) is in turn released to trigger contraction. We review here experiments demonstrating that in cardiac myocytes Ca(2+) signaling and contractile activation are strongly altered by pharmacological inhibition or transcriptional down-regulation of SERCA. On the other hand, kinetics, and intensity… CONTINUE READING

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