The Ca-releasing action of halothane on fragmented sarcoplasmic reticulum.

@article{Ogawa1982TheCA,
  title={The Ca-releasing action of halothane on fragmented sarcoplasmic reticulum.},
  author={Yasuo Ogawa and Nagomi Kurebayashi},
  journal={Journal of biochemistry},
  year={1982},
  volume={92 3},
  pages={899-905}
}
Ca-releasing action of halothane on fragmented sarcoplasmic reticulum (FSR) from bullfrog and rabbit skeletal muscle was examined to understand the mechanism of Ca release in reference to the etiology of malignant hyperthermia. Halothane has dual action on FSR: the Ca release and the inhibition of Ca uptake. On addition of halothane to loaded FSR, a rapid Ca release was followed by a sluggish Ca leakage which was probably due to a decreased capacity for Ca uptake. The properties of the rapid Ca… CONTINUE READING