The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice.

@article{Chiang2009TheCT,
  title={The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice.},
  author={Chien-Sung Chiang and C H Huang and Hockling Chieng and Ya-Ting Chang and Dory Chang and J Chen and Yong-Cyuan Chen and Y. Chen and Hee-sup Shin and Kevin P Campbell and Chien-Chang Chen},
  journal={Circulation research},
  year={2009},
  volume={104 4},
  pages={522-30}
}
Voltage-gated T-type Ca(2+) channels (T-channels) are normally expressed during embryonic development in ventricular myocytes but are undetectable in adult ventricular myocytes. Interestingly, T-channels are reexpressed in hypertrophied or failing hearts. It is unclear whether T-channels play a role in the pathogenesis of cardiomyopathy and what the mechanism might be. Here we show that the alpha(1H) voltage-gated T-type Ca(2+) channel (Ca(v)3.2) is involved in the pathogenesis of cardiac… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Mechanisms Underlying Action of Xinmailong Injection, a Traditional Chinese Medicine in Cardiac Function Improvement

African journal of traditional, complementary, and alternative medicines : AJTCAM • 2017
View 1 Excerpt

Similar Papers

Loading similar papers…