The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms.

@article{Bertolesi2002TheCC,
  title={The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms.},
  author={Gabriel E Bertolesi and Chanjuan Shi and Lindsy Elbaum and Christine A B Jollimore and Gabriela I. Rozenberg and Steven Boots Barnes and Melanie E. M. Kelly},
  journal={Molecular pharmacology},
  year={2002},
  volume={62 2},
  pages={210-9}
}
We show that mitogenic cells expressing T-type Ca(2+) channels (T-channels) are more sensitive to the antiproliferative effects of the drugs pimozide and mibefradil than cells without significant T-channel expression. The growth of Y79 and WERI-Rb1 retinoblastoma cells, as well as MCF7 breast cancer epithelial cells, all of which express T-channel current and mRNA for T-channel subunits, is inhibited by pimozide and mibefradil with IC(50) values between 0.6 and 1.5 microM. Proliferation of… CONTINUE READING

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