The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer.

@article{Spurdle2002TheCP,
  title={The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer.},
  author={Amanda B Spurdle and Bryan Goodwin and Ecushla Hodgson and John L. Hopper and Xiao-qing Chen and David M. Purdie and Margaret R. E. McCredie and Graham G. Giles and Georgia Chenevix-Trench and Christopher Liddle},
  journal={Pharmacogenetics},
  year={2002},
  volume={12 5},
  pages={355-66}
}
CYP3A4 is involved in the metabolism of endogenous steroids, and an allelic variant, CYP3A4*1B, consisting of an A to G polymorphism within the 5'-flanking region termed the nifedipine-specific response element (NFSE) has been associated with high grade and advanced stage of prostate cancers. Because steroid hormone exposure is known to influence breast and ovarian cancer risk, we conducted case-control studies to assess the relationship between CYP3A4*1B and risk of breast or ovarian cancer… CONTINUE READING
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