The CYP1B1_1358_GG genotype is associated with estrogen receptor-negative breast cancer

@article{Justenhoven2007TheCG,
  title={The CYP1B1_1358_GG genotype is associated with estrogen receptor-negative breast cancer},
  author={Christina Justenhoven and Christiane Barbara Pierl and Susanne Haas and Hans-Peter Fischer and Christian Baisch and Ute Hamann and Volker Harth and B. Pesch and Thomas Br{\"u}ning and Caren Vollmert and Thomas Illig and J{\"u}rgen Dippon and Y D Ko and Hiltrud Brauch},
  journal={Breast Cancer Research and Treatment},
  year={2007},
  volume={111},
  pages={171-177}
}
Cytochrome P450 1B1 (CYP1B1) is a major enzyme in the initial catabolic step of estradiol (E2) metabolism and belongs to the multitude of genes regulated by the estrogen receptor alpha (ERα). The common non-synonymous polymorphisms CYP1B1_1358_A>G and CYP1B1_1294_C>G increase CYP1B1 enzymatic activity. Given a relationship between CYP1B1 and breast tumor E2 level as well as E2 level and breast tumor ERα expression it is of interest to know whether CYP1B1 polymorphisms have an impact on the ER… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Similar Papers

Loading similar papers…