The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.

  title={The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.},
  author={Valerie Booth and David W Keizer and Monique B. Kamphuis and I Clark-lewis and Brian D. Sykes},
  volume={41 33},
The structure of IP-10 was solved by NMR spectroscopy and represents the first structure from the class of agonists toward the receptor CXCR3. CXCR3 binding chemokines are unique in their ability to bind receptors from both the CC and CXC classes of chemokine receptors. An unusual structural feature of IP-10 was identified that may provide the basis for the ability of IP-10 to bind both CXCR3 and CCR3. The surface of IP-10 that interacts with the N-terminus of CXCR3 was defined by monitoring… CONTINUE READING

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