The CXCL12-3′A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation

@article{BoguniaKubik2009TheCA,
  title={The CXCL12-3′A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation},
  author={Katarzyna Bogunia-Kubik and Anna Gieryng and Dorota Dlubek and Andrzej Lange},
  journal={Bone Marrow Transplantation},
  year={2009},
  volume={44},
  pages={273-278}
}
The interaction between CXCL12 and its receptor CXCR4 plays a crucial role in the homing and mobilization of haematopoietic progenitors. We investigated the putative association between a CXCL12 gene polymorphism, the G → A transition at position 801 in the 3′-untranslated region (3′UTR), and the yield of CD34+ progenitors in 65 healthy allogeneic transplant donors who received G-CSF. Importantly, in this setting, the analysis was not biased by background disease or chemotherapy. The 3′UTR… CONTINUE READING

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