The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue

Abstract

Chemokine CXCL12 gradients drive chemotaxis in a CXCR4-dependent mechanism and have been implicated in cancer metastasis. While CXCL12 gradients are typically studied in organized, defined environments, the tumor microenvironment is disorganized. In vivo, CXCL12 gradients depend on many factors: the number and arrangement of cells secreting and degrading… (More)
DOI: 10.1371/journal.pone.0187357

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Cite this paper

@inproceedings{Spinosa2017TheCS, title={The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue}, author={Phillip C Spinosa and Kathryn E. Luker and Gary D. Luker and Jennifer J. Linderman}, booktitle={PloS one}, year={2017} }