The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes.

Abstract

The cellular effects of stromal cell-derived factor-1 (SDF-1) are mediated primarily by binding to the CXC chemokine receptor-4. We report in this study that SDF-1 and its peptide analogues induce a concentration- and time-dependent accumulation of phosphatidylinositol-(3,4,5)-trisphosphate (PtdIns(3,4,5)P3) in Jurkat cells. This SDF-1-stimulated generation… (More)

Topics

10 Figures and Tables

Cite this paper

@article{Sotsios1999TheCC, title={The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes.}, author={Y Sotsios and Gillian C. Whittaker and John Westwick and Stephen Geoffrey Ward}, journal={Journal of immunology}, year={1999}, volume={163 11}, pages={5954-63} }