The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.

Abstract

HPK1, a member of mammalian Ste20-like serine/threonine kinases, is lost in >95% pancreatic cancer through proteasome-mediated degradation. However, the mechanism of HPK1 loss has not been defined. The aims of this study are to identify the ubiquitin ligase and to examine the mechanisms that targets HPK1 degradation. We found that the CUL7/Fbxw8 ubiquitin… (More)
DOI: 10.1074/jbc.M113.520106

Topics

Cite this paper

@article{Wang2014TheCA, title={The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.}, author={Hua Wang and Yue Chen and Ping Lin and Lei Li and Guisheng Zhou and Guangchao Liu and Craig D. Logsdon and Jianping Jin and James L Abbruzzese and Tse-Hua Tan and Huamin Wang}, journal={The Journal of biological chemistry}, year={2014}, volume={289 7}, pages={4009-17} }