The CSC connects three major axonemal complexes involved in dynein regulation

@inproceedings{Heuser2012TheCC,
  title={The CSC connects three major axonemal complexes involved in dynein regulation},
  author={Thomas Heuser and Erin E. Dymek and Jianfeng Lin and Elizabeth F. Smith and Daniela Nicastro},
  booktitle={Molecular biology of the cell},
  year={2012}
}
Motile cilia and flagella are highly conserved organelles that play important roles in human health and development. We recently discovered a calmodulin- and spoke-associ-ated complex (CSC) that is required for wild-type motility and for the stable assembly of a subset of radial spokes. Using cryo-electron tomography, we present the first structure-based localization model of the CSC. Chlamydomonas flagella have two full-length radial spokes, RS1 and RS2, and a shorter RS3 homologue, the RS3… CONTINUE READING
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