The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene.

@article{Senechal1996TheCA,
  title={The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene.},
  author={Kristen Senechal and Judy Stoner Halpern and Charles L Sawyers},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 38},
  pages={23255-61}
}
The CRKL adaptor protein was recently identified as a substrate for the BCR-ABL tyrosine kinase in patients with chronic myelogenous leukemia, but its function is unknown. Here we report that CRKL is phosphorylated when overexpressed, activates RAS and JUN kinase signaling pathways, and transforms fibroblasts in a RAS-dependent fashion. We examined the potential role of CRKL in BCR-ABL function by deleting the CRKL binding site in BCR-ABL. This mutant BCR-ABL protein shows a 50% reduction in… CONTINUE READING

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