The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA

@article{Fonfara2016TheCD,
  title={The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA},
  author={Ines Fonfara and Hagen Richter and Majda Bratovi{\vc} and Ana{\"i}s Le Rhun and E. Charpentier},
  journal={Nature},
  year={2016},
  volume={532},
  pages={517-521}
}
CRISPR–Cas systems that provide defence against mobile genetic elements in bacteria and archaea have evolved a variety of mechanisms to target and cleave RNA or DNA. [...] Key Result Cpf1 cleaves pre-crRNA upstream of a hairpin structure formed within the CRISPR repeats and thereby generates intermediate crRNAs that are processed further, leading to mature crRNAs.Expand
Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR-Cas Systems.
RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a
Structures and mechanisms of CRISPR RNA-guided effector nucleases.
The Conspicuity of CRISPR-Cpf1 System as a Significant Breakthrough in Genome Editing
RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.
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