The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA

@article{Fonfara2016TheCD,
  title={The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA},
  author={Ines Fonfara and Hagen Richter and Majda Bratovi{\vc} and Ana{\"i}s Le Rhun and Emmanuelle Charpentier},
  journal={Nature},
  year={2016},
  volume={532},
  pages={517-521}
}
  • Ines Fonfara, Hagen Richter, +2 authors Emmanuelle Charpentier
  • Published 2016
  • Medicine, Biology
  • Nature
  • CRISPR–Cas systems that provide defence against mobile genetic elements in bacteria and archaea have evolved a variety of mechanisms to target and cleave RNA or DNA. [...] Key Result Cpf1 cleaves pre-crRNA upstream of a hairpin structure formed within the CRISPR repeats and thereby generates intermediate crRNAs that are processed further, leading to mature crRNAs.Expand Abstract

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 371 CITATIONS, ESTIMATED 60% COVERAGE

    Structures and mechanisms of CRISPR RNA-guided effector nucleases.

    VIEW 2 EXCERPTS
    CITES BACKGROUND

    The Conspicuity of CRISPR-Cpf1 System as a Significant Breakthrough in Genome Editing

    VIEW 15 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    FILTER CITATIONS BY YEAR

    2016
    2020

    CITATION STATISTICS

    • 22 Highly Influenced Citations

    • Averaged 81 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 42 REFERENCES