The CRISPR/Cas immune system is an operon regulated by LeuO, H-NS, and leucine-responsive regulatory protein in Salmonella enterica serovar Typhi.

@article{MedinaAparicio2011TheCI,
  title={The CRISPR/Cas immune system is an operon regulated by LeuO, H-NS, and leucine-responsive regulatory protein in Salmonella enterica serovar Typhi.},
  author={Liliana Medina-Aparicio and Javier Esteban Rebollar-Flores and Ana L Gallego-Hernandez and Alejandra Mateo V{\'a}zquez and Leticia Olvera and Rosa-Maria Gutierrez-Rios and E. Barrera Calva and Ismael Hern{\'a}ndez-Lucas},
  journal={Journal of bacteriology},
  year={2011},
  volume={193 10},
  pages={2396-407}
}
Prokaryotes have developed multiple strategies to survive phage attack and invasive DNA. Recently, a novel genetic program denominated the CRISPR/Cas system was demonstrated to have a role in these biological processes providing genetic immunity. This defense mechanism is widespread in the Archaea and Bacteria, suggesting an ancient origin. In the last few years, progress has been made regarding the functionality of the CRISPR/Cas system; however, many basic aspects of the system remain unknown… CONTINUE READING

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