The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

@article{Garneau2010TheCB,
  title={The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA},
  author={Josiane E. Garneau and M. Dupuis and M. Villion and D. Romero and R. Barrangou and P. Boyaval and C. Fremaux and P. Horvath and A. H. Magad{\'a}n and S. Moineau},
  journal={Nature},
  year={2010},
  volume={468},
  pages={67-71}
}
Bacteria and Archaea have developed several defence strategies against foreign nucleic acids such as viral genomes and plasmids. [...] Key Result Here we show that the Streptococcus thermophilus CRISPR1/Cas system can also naturally acquire spacers from a self-replicating plasmid containing an antibiotic-resistance gene, leading to plasmid loss. Acquired spacers that match antibiotic-resistance genes provide a novel means to naturally select bacteria that cannot uptake and disseminate such genes.Expand
Genomic impact of CRISPR immunization against bacteriophages.
CRISPR Interference Directs Strand Specific Spacer Acquisition
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