The CP2 domain of leucyl-tRNA synthetase is crucial for amino acid activation and post-transfer editing.

Abstract

Leucyl-tRNA synthetase (LeuRS) has an insertion domain, called connective peptide 2 (CP2), either directly preceding or following the editing domain (CP1 domain), depending on the species. The global structures of the CP2 domains from all LeuRSs are similar. Although the CP1 domain has been extensively explored to be responsible for hydrolysis of mischarged… (More)
DOI: 10.1074/jbc.M806745200

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