The COX-2 pathway is essential during early stages of skeletal muscle regeneration.

@article{Bondesen2004TheCP,
  title={The COX-2 pathway is essential during early stages of skeletal muscle regeneration.},
  author={Brenda A. Bondesen and Stephen T. Mills and Kristy M Kegley and Grace K Pavlath},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={287 2},
  pages={
          C475-83
        }
}
Skeletal muscle regeneration comprises several overlapping cellular processes, including inflammation and myogenesis. Prostaglandins (PGs) may regulate muscle regeneration, because they modulate inflammation and are involved in various stages of myogenesis in vitro. PG synthesis is catalyzed by different isoforms of cyclooxygenase (COX), which are inhibited by nonsteroidal anti-inflammatory drugs. Although experiments employing nonsteroidal anti-inflammatory drugs have implicated PGs in tissue… 
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