The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII.

@article{Yamazaki2013TheCV,
  title={The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII.},
  author={Tomoko G. Yamazaki and Jun-ichi Suehiro and Hideki Miyazaki and Takashi Minami and Tatsuhiki Kodama and Kohei Miyazono and Tetsuro Watabe},
  journal={The Biochemical journal},
  year={2013},
  volume={452 2},
  pages={
          345-57
        }
}
The COUP-TFII (chicken ovalbumin upstream promoter-transcription factor II) nuclear receptor, which is composed of a DNA-binding domain and a ligand-binding domain, exerts pleiotropic effects on development and cell differentiation by regulating the transcription of its target genes, including Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1), which plays important roles in catabolism of cholesterol in the liver. Although multiple variants of COUP-TFII exist, their roles in the… CONTINUE READING

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