The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.

@article{Markgraf2009TheCS,
  title={The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.},
  author={Daniel F Markgraf and Franziska Ahnert and Henning Arlt and Muriel C Mari and Karolina Peplowska and Nadine Epp and Janice Griffith and Fulvio Reggiori and Christian Ungermann},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 24},
  pages={
          5276-89
        }
}
Membrane tethering, the process of mediating the first contact between membranes destined for fusion, requires specialized multisubunit protein complexes and Rab GTPases. In the yeast endolysosomal system, the hexameric HOPS tethering complex cooperates with the Rab7 homolog Ypt7 to promote homotypic fusion at the vacuole, whereas the recently identified… CONTINUE READING