The COP9 signalosome.

@article{Wei2003TheCS,
  title={The COP9 signalosome.},
  author={Ning Wei and Xing Wang Deng},
  journal={Annual review of cell and developmental biology},
  year={2003},
  volume={19},
  pages={
          261-86
        }
}
  • N. Wei, X. Deng
  • Published 28 November 2003
  • Biology
  • Annual review of cell and developmental biology
The COP9 signalosome (CSN) is composed of eight distinct subunits and is highly homologous to the lid sub-complex of the 26S proteasome. CSN was initially defined as a repressor of photomorphogenesis in Arabidopsis, and it has now been found to participate in diverse cellular and developmental processes in various eukaryotic organisms. Recently, CSN was revealed to have a metalloprotease activity centered in the CSN5/Jab1 subunit, which removes the post-translational modification of a ubiquitin… 
View on PubMed
yale.edu
498 Citations
Highly Influential Citations
24
Background Citations
233
Methods Citations
8
Results Citations
2

Figures and Tables from this paper

498 Citations

Citation Type

Citation Type

The COP9 signalosome: more than a protease.
Mammalian COP9 signalosome
TLDR
The physiological role and the cellular function of the mammalian CSN in terms of the regulation of cell proliferation is discussed and a review of recent findings is summarized.
Signaling: COP9 Signalosome
TLDR
The COP9 signalosome has an isopeptidase activity which removes the NEDD8 peptide from the cullin–RING ubiquitin ligases (CRLs), which ensures the proper function of the CRLs.
COP9 Signalosome: discovery, conservation, activity, and function.
TLDR
The discovery, composition, structure, and function of CSN in the regulation of plant development in response to external (light and temperature) and internal cues (phytohormones) are summarized.
Revisiting the COP9 signalosome as a transcriptional regulator
TLDR
The mechanisms by which the CSN acts as a transcriptional regulator are re‐evaluated, and it is suggested that they could extend beyond the regulation of protein stability.
The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription.
Consequences of COP9 signalosome and 26S proteasome interaction
TLDR
It is shown that the COP9 signalosome directly interacts with the 26S proteasome and competes with the lid, which has consequences for the peptidase activity of the 27S prote as well as the possible role of super‐complexes composed of the CSN, the 26s proteasomes and of Ub ligases in the regulation of protein stability.
COP9 signalosome function in the DDR
Roles of COP9 signalosome in cancer
TLDR
The mechanisms by which some CSN subunits are involved in cancer are discussed to provide a much needed perspective regarding COP9 in cancer research, hoping that these insights will lay the groundwork for cancer intervention.
The COP9 Signalosome Regulates Skp2 Levels and Proliferation of Human Cells*
TLDR
The data indicate that the CSN is necessary to ensure the assembly of a functional SCFSkp2 complex and therefore contributes to cell cycle regulation of human cells.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 193 REFERENCES
COP9 signalosome revisited: a novel mediator of protein degradation.
The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis.
TLDR
The COP9 signalosome appears to be a platform connecting signalling with proteolysis, and two activities associated with the CSN have been identified so far: a protein kinase and a deneddylase.
The COP9 signalosome: regulating plant development through the control of proteolysis.
TLDR
This review discusses the current understanding of the COP9 signalosome function with particular emphasis on its recently defined role in modulating a wide variety of cellular processes by regulating specific protein degradation events.
Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome
TLDR
It is proposed that the broad spectrum of activities previously attributed to CSN subunits—including repression of photomorphogenesis, activation of JUN, and activation of p27 nuclear export—underscores the importance of dynamic cycles of NEDD8 attachment and removal in biological regulation.
Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human.
  • N. Wei, X. Deng
  • Biology, Environmental Science
    Trends in genetics : TIG
  • 1999
COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.
TLDR
P phenotypic characterization of csn5 and csn4 mutants indicates that they show both shared and unique phenotypes, which suggest specific roles for each subunit, and biochemical analysis indicates that the different subunits are found in both CSN-dependent andCSN-independent forms.
Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms.
TLDR
Two signalosome subunits, Csn1 and Csn2, are required to regulate ribonucleotide reductase (RNR) through the degradation of a small protein, Spd1, that acts to anchor the small RNR subunit in the nucleus.
Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin Response
TLDR
It is shown that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-of-function mutants of the E3 ubiquitin ligase SCFTIR1, and that the COP9 signosome was required for efficient degradation of PSIAA6, a candidate substrate of SC FTIR1.
JAB1/CSN5 and the COP9 signalosome
The Jun activating binding protein (JAB1) specifically stabilizes complexes of c‐Jun or JunD with AP‐1 sites, increasing the specificity of target gene activation by AP‐1 proteins. JAB1 is also known…
A role of Arabidopsis COP9 signalosome in multifaceted developmental processes revealed by the characterization of its subunit 3.
TLDR
It is reported that Arabidopsis FUS11 gene encodes the subunit 3 of the COP9 signalosome (CSN3), substantiates a hypothesis that the COP 9 signalosomes is involved in multifaceted developmental processes through regulating proteasome-mediated protein degradation.
...
1
2
3
4
5
...