The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development.

@article{Kress2012TheCS,
  title={The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development.},
  author={M{\'a}rcia Regina Von Zeska Kress and Rebekka Harting and {\"O}zg{\"u}r Bayram and Martin Christmann and Henriette Irmer and Oliver Valerius and Josua Schinke and Gustavo Henrique Goldman and Gerhard H Braus},
  journal={Molecular microbiology},
  year={2012},
  volume={83 6},
  pages={1162-77}
}
Defects in the COP9 signalosome (CSN) impair multicellular development, including embryonic plant or animal death or a block in sexual development of the fungus Aspergillus nidulans. CSN deneddylates cullin-RING ligases (CRLs), which are activated by covalent linkage to ubiquitin-like NEDD8. Deneddylation allows CRL disassembly for subsequent reassembly. An attractive hypothesis is a consecutive order of CRLs for development, which demands repeated cycles of neddylation and deneddylation for… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 82 references

A dual E3

  • D. C. Scott, J. K. Monda, +4 authors B. A. Schulman
  • 2010
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…