The COP9 signalosome

  title={The COP9 signalosome},
  author={Michael L. Glickman},
  journal={Current Biology},
But what does it really do? This is the $64,000 question. If we must join in the rampant speculation, the CSN probably has multiple functions. It may serve as a master dock, bringing together proteins, such as a kinase, its substrate, and the proteasome. The CSN might even be an alternative or additional proteasome lid, shuttling ubiquitinated substrates from the SCF to the proteasome. Alternatively, the CSN itself may be ‘inactive’, and the reported activities may lie in its individual… CONTINUE READING

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