The COMT val158met Polymorphism Is Associated with Early Pubertal Development, Height and Cortical Bone Mass in Girls

@article{Eriksson2005TheCV,
  title={The COMT val158met Polymorphism Is Associated with Early Pubertal Development, Height and Cortical Bone Mass in Girls},
  author={A. Eriksson and Miia Suuriniemi and Anitta Mahonen and Sulin Cheng and C Ohlsson},
  journal={Pediatric Research},
  year={2005},
  volume={58},
  pages={71-77}
}
Estrogens are involved in accretion of bone mass during puberty. Catechol-O-Methyltransferase (COMT) is involved in the degradation of estrogens. In this cross-sectional study we investigated associations between the COMT val158met polymorphism, which results in a 60–75% difference in enzyme activity between the val (high activity = H) and the met (low activity = L) variant, and skeletal phenotypes in 246 healthy pre/early pubertal girls. Girls with COMTLL were 5.4 cm taller than COMTHH girls… CONTINUE READING
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