The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.

@article{Shilatifard2012TheCF,
  title={The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.},
  author={Ali Shilatifard},
  journal={Annual review of biochemistry},
  year={2012},
  volume={81},
  pages={65-95}
}
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4) methylase identified over 10 years ago. Since then, it has been demonstrated that Set1/COMPASS and its enzymatic product, H3K4 methylation, is highly conserved across the evolutionary tree. Although there is only one COMPASS in yeast, Drosophila possesses three and humans bear six COMPASS family members, each capable of methylating H3K4 with nonredundant functions. In yeast, the histone H2B monoubiquitinase Rad6… CONTINUE READING
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