The COI mitochondrial gene encodes a minor histocompatibility antigen presented by H2-M3.

@article{Morse1996TheCM,
  title={The COI mitochondrial gene encodes a minor histocompatibility antigen presented by H2-M3.},
  author={Malika C Morse and Geoff Bleau and Vikram M. Dabhi and F H{\'e}tu and Elliot Drobetsky and Kirsten Fischer Lindahl and Claude Perreault},
  journal={Journal of immunology},
  year={1996},
  volume={156 9},
  pages={3301-7}
}
We found that (LP x C57BL/6)F1 mice could raise a CTL response against parental C57BL/6 cells. These CTLs recognized a maternally transmitted, H2-M3wt-restricted, minor histocompatibility Ag (MiHA) that is widely distributed among many strains of mice and encoded by the COI mitochondrial gene. The wild-type MiHA is the COI N-terminal hexapeptide. Sequencing the 5' end of the COI gene in LP and C57BL/6 mice showed that the LP allele arose by a T-->C transition in the third codon, which caused… CONTINUE READING
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