The CNS site of glucocorticoid negative feedback during LPS- and psychological stress-induced fevers.

@article{Morrow1996TheCS,
  title={The CNS site of glucocorticoid negative feedback during LPS- and psychological stress-induced fevers.},
  author={Lynn Morrow and John L. McClellan and Jan Kl{\'i}r and Matthew Jay Kluger},
  journal={The American journal of physiology},
  year={1996},
  volume={271 3 Pt 2},
  pages={R732-7}
}
Glucocorticoids exert negative feedback in the anterior hypothalamus (AH) during lipopolysaccharide (LPS)-induced fevers, but the central location of their negative feedback during psychological stress-induced fever has not been determined. To confirm that glucocorticoid modulation of LPS fever occurs in the AH, adrenalectomized animals were injected intrahypothalamically with either 0.25 ng of corticosterone or vehicle followed by 50 micrograms/kg LPS intraperitoneally. Animals pretreated with… CONTINUE READING