The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy.

@article{Tanga2005TheCR,
  title={The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy.},
  author={Flobert Y Tanga and Nancy Nutile-McMenemy and Joyce A Deleo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 16},
  pages={5856-61}
}
Neuropathic pain remains a prevalent and persistent clinical problem because of our incomplete understanding of its pathogenesis. This study demonstrates for the first time, to our knowledge, a critical role for CNS innate immunity by means of microglial Toll-like receptor 4 (TLR4) in the induction phase of behavioral hypersensitivity in a mouse and rat model of neuropathy. We hypothesized that after L5 nerve transection, CNS neuroimmune activation and subsequent cytokine expression are… CONTINUE READING
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