The CNS lesion scar: new vistas on an old regeneration barrier

@article{Stichel1998TheCL,
  title={The CNS lesion scar: new vistas on an old regeneration barrier},
  author={Christine C. Stichel and Hans Werner M{\"u}ller},
  journal={Cell and Tissue Research},
  year={1998},
  volume={294},
  pages={1-9}
}
Scar formation represents a reaction of nervous tissue to any form of physical injury. Research over the past decade has demonstrated that the scar composed of glial cells and several extracellular matrix molecules constitutes an obstacle to axon regeneration in the CNS. This review briefly summarizes the current knowledge on (a) the structural and functional features of the lesion scar and (b) the development of therapeutic interventions to override this regeneration barrier. 

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 91 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 105 references

Axon growth through the modified CNS scar

  • CC Stichel, H Niermann, S Hermanns, F Lausberg, D D'Urso, HW Müller
  • Eur J Neurosci Suppl
  • 1998
Highly Influential
5 Excerpts

Massive regeneration of lesioned CNS axons across scar tissue following modulation of the lesion interface

  • CC Stichel, S Hermanns, F Lausberg, H Niermann, H Luhmann, HW Müller
  • Eur J Neurosci Suppl
  • 1998
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…